GLENDALE, Ariz. — Former North Dakota State quarterback Trey Lance made his first career NFL start against the Kyler Murray-led Arizona Cardinals on Sunday, Oct. 10, at State Farm Stadium.

Murray threw a fourth-quarter TD to receiver DeAndre Hopkins to help lift the Cardinals to a 17-10 victory as Arizona improved to 5-0 overall to remain the lone unbeaten team in the NFL.

“I’ve got to do better, make more plays, obviously disappointed." Lance said after the game. "I really wanted to win that game.”

Lance was the No. 3 overall selection in the most recent NFL Draft. The 6-foot-4, 226-pound Lance was announced the starter late in the week after starter Jimmy Garoppolo was ruled out with a lower leg injury. Lance completed 15 of 29 passes for 192 yards with one interception in his first NFL start. He also rushed for 89 yards on 16 attempts.

“I thought he did some really good things. It definitely wasn’t perfect, but no one ever has been," 49ers head coach Kyle Shanahan said of Lance after the game. "Overall, I think if we could have done a little bit better around him. I thought he did good enough to win."

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The Cardinals had a 10-0 lead at halftime. Lance completed 5 of 11 passes for 63 yards with in interception in the first half. He rushed for 47 yards on nine attempts in the opening half, including a run that was stopped inches from the goal line on a fourth-and-goal play in the second quarter.

“I’ve got to get in the end zone for my team,” Lance said of being stopped right at the goal line. “That’s a big one, a missed opportunity.”

Arizona Cardinals linebacker Chandler Jones (55) stops San Francisco 49ers quarterback Trey Lance (5) from scoring a touchdown during the first half at State Farm Stadium. Chris Coduto / USA TODAY Sports
Arizona Cardinals linebacker Chandler Jones (55) stops San Francisco 49ers quarterback Trey Lance (5) from scoring a touchdown during the first half at State Farm Stadium. Chris Coduto / USA TODAY Sports

Lance led the 49ers (2-3) on a touchdown drive late in the third quarter to cut into the Arizona lead. A Deebo Samuel 13-yard scoring run trimmed the lead to 10-7 with 1 minute, 42 seconds to play in the third. That was the lone San Francisco TD.

"He was poised," San Francisco offensive tackle Trent Williams said of Lance. "He was poised, he was confident. I felt like Trey gave us a chance to win."

Lance came on in relief of Garoppolo last week and completed 9 of 18 passes for 157 yards and two touchdowns in a 28-21 home loss against the Seattle Seahawks.

Lance threw his interception on the first drive of the game against the Cardinals. He overthrew receiver Travis Benjamin on the play. Cardinals safety Budda Baker picked off the errant throw.

"I just missed Travis," Lance said. "Travis was wide open, the ball just sailed on me a little bit climbing the pocket."

Lance is 0-1 as an NFL starter. He was undefeated in 17 starts at NDSU, including a 16-0 NCAA Division I FCS national championship season in 2019.

Lance is the fourth youngest QB at the time of his first NFL start in the Super Bowl era (since 1966) at 21 years, 154 days old.

"I'm super proud of these guys, defensively, offensively, how we competed," Lance said. "We're going to learn a lot from it and we're going to better for it."

Angie and Carlton Lance, Trey's parents, were in attendance at State Farm Stadium. They were shown in multiple cutaway shots during the broadcast.

"I don't see why there's any question of whether he'll be fine or not," Williams said of Trey Lance. "I thought we moved the ball up and down the field. I feel like he made some dynamic plays with his legs, he made some plays with his arm. ... I feel like Trey is going to be fine. There's nothing I've seen that makes me think otherwise."

Below are photos, highlights and reaction to Lance's first start:

Arizona Cardinals defensive end J.J. Watt (99) tackles San Francisco 49ers quarterback Trey Lance (5) during the first half at State Farm Stadium. Chris Coduto / USA TODAY Sports
Arizona Cardinals defensive end J.J. Watt (99) tackles San Francisco 49ers quarterback Trey Lance (5) during the first half at State Farm Stadium. Chris Coduto / USA TODAY Sports

San Francisco 49ers quarterback Trey Lance (5) loses his helmet while tackled by Arizona Cardinals linebacker Tanner Vallejo (51) and free safety Jalen Thompson (34) during the third quarter at State Farm Stadium. Michael Chow / USA TODAY Sports
San Francisco 49ers quarterback Trey Lance (5) loses his helmet while tackled by Arizona Cardinals linebacker Tanner Vallejo (51) and free safety Jalen Thompson (34) during the third quarter at State Farm Stadium. Michael Chow / USA TODAY Sports

Arizona Cardinals defensive tackle Leki Fotu (95) deflects a pass by San Francisco 49ers quarterback Trey Lance (5) during the first quarter at State Farm Stadium. Michael Chow / USA TODAY Sports
Arizona Cardinals defensive tackle Leki Fotu (95) deflects a pass by San Francisco 49ers quarterback Trey Lance (5) during the first quarter at State Farm Stadium. Michael Chow / USA TODAY Sports

Arizona Cardinals defensive end J.J. Watt (99) shakes hands with San Francisco 49ers quarterback Trey Lance (5) after the Cardinals beat the 49ers 17-10 at State Farm Stadium. Chris Coduto / USA TODAY Sports
Arizona Cardinals defensive end J.J. Watt (99) shakes hands with San Francisco 49ers quarterback Trey Lance (5) after the Cardinals beat the 49ers 17-10 at State Farm Stadium. Chris Coduto / USA TODAY Sports

Arizona Cardinals linebacker Chandler Jones (55) reacts with linebacker Markus Golden (44) after stopping San Francisco 49ers quarterback Trey Lance (5) from scoring a touchdown during the first half at State Farm Stadium. Chris Coduto / USA TODAY Sports
Arizona Cardinals linebacker Chandler Jones (55) reacts with linebacker Markus Golden (44) after stopping San Francisco 49ers quarterback Trey Lance (5) from scoring a touchdown during the first half at State Farm Stadium. Chris Coduto / USA TODAY Sports

Arizona Cardinals defensive end J.J. Watt (99) tackles San Francisco 49ers quarterback Trey Lance (5) during the first half at State Farm Stadium. Chris Coduto / USA TODAY Sports
Arizona Cardinals defensive end J.J. Watt (99) tackles San Francisco 49ers quarterback Trey Lance (5) during the first half at State Farm Stadium. Chris Coduto / USA TODAY Sports

Arizona Cardinals defensive end Zach Allen (94) sacks San Francisco 49ers quarterback Trey Lance (5) during the second quarter at State Farm Stadium. Michael Chow / USA TODAY Sports
Arizona Cardinals defensive end Zach Allen (94) sacks San Francisco 49ers quarterback Trey Lance (5) during the second quarter at State Farm Stadium. Michael Chow / USA TODAY Sports

San Francisco 49ers quarterback Trey Lance (5) throws a pass against the Arizona Cardinals during the third quarter at State Farm Stadium. Michael Chow / USA TODAY Sports
San Francisco 49ers quarterback Trey Lance (5) throws a pass against the Arizona Cardinals during the third quarter at State Farm Stadium. Michael Chow / USA TODAY Sports

San Francisco 49ers quarterback Trey Lance (5) is sacked by Arizona Cardinals defensive end Zach Allen (94) as 49ers offensive tackle Mike McGlinchey (69) tries to block him during the third quarter at State Farm Stadium. Michael Chow / USA TODAY Sports
San Francisco 49ers quarterback Trey Lance (5) is sacked by Arizona Cardinals defensive end Zach Allen (94) as 49ers offensive tackle Mike McGlinchey (69) tries to block him during the third quarter at State Farm Stadium. Michael Chow / USA TODAY Sports

San Francisco 49ers quarterback Trey Lance (5) warms up before the game against the Arizona Cardinals on Sunday, Oct. 10, 2021, at State Farm Stadium. Chris Coduto / USA TODAY Sports
San Francisco 49ers quarterback Trey Lance (5) warms up before the game against the Arizona Cardinals on Sunday, Oct. 10, 2021, at State Farm Stadium. Chris Coduto / USA TODAY Sports

San Francisco 49ers quarterback Trey Lance (5) warms up before the game against the Arizona Cardinals on Sunday, Oct. 10, 2021, at State Farm Stadium. Chris Coduto / USA TODAY Sports
San Francisco 49ers quarterback Trey Lance (5) warms up before the game against the Arizona Cardinals on Sunday, Oct. 10, 2021, at State Farm Stadium. Chris Coduto / USA TODAY Sports

Arizona Cardinals linebacker Chandler Jones (55) reacts after stopping San Francisco 49ers quarterback Trey Lance (5) from scoring a touchdown during the first half at State Farm Stadium. Chris Coduto / USA TODAY Sports
Arizona Cardinals linebacker Chandler Jones (55) reacts after stopping San Francisco 49ers quarterback Trey Lance (5) from scoring a touchdown during the first half at State Farm Stadium. Chris Coduto / USA TODAY Sports

San Francisco 49ers quarterback Trey Lance (5) is tackled by Arizona Cardinals free safety Jalen Thompson (34) during the third quarter at State Farm Stadium. Michael Chow / USA TODAY Sports
San Francisco 49ers quarterback Trey Lance (5) is tackled by Arizona Cardinals free safety Jalen Thompson (34) during the third quarter at State Farm Stadium. Michael Chow / USA TODAY Sports