SANTA CLARA — While Jimmy Garoppolo practiced Monday for the first time since his Oct. 3 calf injury, fellow quarterback Trey Lance did not take the field alongside him. Lance was diagnosed with a left knee sprain from his Oct. 10 starting debut.

Garoppolo's right calf looks unhindered and that puts him on target to reprise his starting role Sunday night when the 49ers (2-3) host the Indianapolis Colts (2-4).

The game held the possibility that former North Dakota State and current Colts quarterback Carson Wentz could face a 49ers team led by Lance, also a former Bison QB.

"Seemed like Jimmy," left tackle Trent Williams said. "He was fighting to get back last week. Seeing him this week, he seems like he's been ready. If there was a game last week, he'd probably have been OK to play. So, yeah, Jimmy looks like Jimmy."

Garoppolo warmed up alongside Nate Sudfeld, who will likely be elevated again from the practice squad to serve as the backup for a second straight game if Lance is inactive Sunday.

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Lance was projected to miss one to two weeks because of the knee sprain that was diagnosed a day after the 49ers' 17-10 loss at Arizona, in which the rookie had 16 carries.