MINNEAPOLIS -- Tommy La Stella went 3-for-5, including what proved to be the game-winning home run in the sixth inning, and Shohei Ohtani hit his first home run of the season to lead the Los Angeles Angels to a 5-4 victory over the Minnesota Twins on Monday night in Minneapolis.

La Stella broke a 4-4 tie with his team-leading 10th homer of the season into the left field bleachers, becoming the first Angels' left-handed batter since Mo Vaughn in 1999 to hit 10 home runs in his first 36 games of a season.

Mike Trout and Albert Pujols both went 3-for-5, Ohtani went 2-for-3 with two walks and two RBIs and Kole Calhoun added two hits for Los Angeles which won for the fifth time in seven games.

Tyler Skaggs (4-3) picked up the win, allowing four runs on five hits over five innings. Hansel Robles pitched a perfect ninth to notch his fourth save.

Jorge Polanco and Marwin Gonzalez each homered for Minnesota, which has lost back-to-back games for just the third time this season. Jose Berrios (6-2), who had won a career-best five consecutive starts, took the loss, failing to go six innings for the first time in 10 starts. Berrios allowed allowing a career-worst 12 hits and five runs over 5 2/3 innings. He walked three and struck out three.

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The Twins took a 2-0 lead in the first when Mitch Garver led off with a walk and then scored on Polanco's eighth home run of the season, a 401-foot drive into the second deck in left field.

The Angels rebounded to take a 3-2 lead in the third when they sent eight men to the plate. La Stella opened the inning with a single and then scored on a single by Trout that bounced past Gonzalez and rolled into the right field corner for a two-base error. Ohtani then followed with a 429-foot homer off the facing of the second deck above the bullpen in left-center.

Los Angeles extended its lead to 4-2 in the fifth when Andrelton Simmons led off with a single, stole second and then scored on a single by Pujols.

The Twins tied it in the bottom half of the inning on a two-run homer by Gonzalez into the second deck in left-center, his fourth of the season.

La Stella, who entered the season with 10 career home runs in 947 at-bats, then put the Angels back in front, 5-4, in the sixth with his 10th homer of the season and the game-winner.